$list[110] = "\"/\$HOME/etc/rm2_start\"\n";
$list[210] = "\"/\$HOME/etc/rm2_stop\"\n";

$ 
$ # show what lines [109..113] and [209..213] look like before script is run
$ perl -lne 'print $.,"\t",$_ if 109..113 or 209..213' status
109     This is line 109                                     
110     This is line 110                                     
111     This is line 111                                     
112     This is line 112                                     
113     This is line 113                                     
209     This is line 209                                     
210     This is line 210                                     
211     This is line 211
212     This is line 212
213     This is line 213
$
$ # show the modified Perl script
$ cat -n change_status.pl
     1  #!/usr/bin/perl
     2
     3  $file = "status";
     4  $RM2 = "BLAH";
     5
     6  open($fh, "<", $file) or die "Could not open $file: $!\n";
     7  @list = <$fh>;
     8  close($fh);
     9
    10  $list[30] = "RM=\"rm2\"\n";                   # this will affect line 31
    11  $list[37] =~ s/"$/ $RM2"/;                    # this will affect line 38
    12  $list[42] = "rm2DESC=\"Result Manager2\"\n";  # this will affect line 43
    13  $list[110] = "\"/\$HOME/etc/rm2_start\"\n";   # this will affect line 111
    14  $list[210] = "\"/\$HOME/etc/rm2_stop\"\n";    # this will affect line 211
    15
    16  open($fh, ">", $file) or die "Could not open $file: $!\n";
    17  print $fh @list;
    18  close($fh);
    19
$
$ # run the script
$ perl change_status.pl
$
$ # show what lines [109..113] and [209..213] look like after script is run
$ perl -lne 'print $.,"\t",$_ if 109..113 or 209..213' status
109     This is line 109
110     This is line 110
111     "/$HOME/etc/rm2_start"
112     This is line 112
113     This is line 113
209     This is line 209
210     This is line 210
211     "/$HOME/etc/rm2_stop"
212     This is line 212
213     This is line 213
$
$