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Thank you! I'm able to get the list column # into an array, but still don't know how to print those corresponding columns out.

The data is something like:
000 A B C D 2.22 3.4 1.03 .....
001 B...

Sorry I didn't make it clear.
Yes, the file is tab delimited.

The dataset I'm working on is about 450G, with about 7000 colums and 30,000,000 rows.
I want to extract about 2000 columns from the original file to form a new file.
I have the list of number of...