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Thanks - I modified that a bit and it appears to be doing the job nicely. Thanks again!

sed -i 's/GH:IJKLMNOP_QRS_TUV\/*$/GH:IJKLMNOP_QRS_TUV/g' file.txt

Hello,

I apologize for asking what is probably a simple question but I have been unable to understand the other posts on the topic. I have a file that has the following several lines:

ABC DEF...