I am not sure; in our business, there is not so much sco knowhow.
We only do relinking the kernel after changing ip addresses with netconfig. And it works (1-3 years ago)
in our business we have a formerly (few years ago) installed computer with an openserver SCO 5.05
there are 3 network cards in it. one on board and two 3Com-cards
Looking with ifconfig...