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Don,

Thank you very much for your brief explanation. I will be in touch with you through this site. Have a great day :)

sed -i "/ 21$/d" file

it will also work fine for your data, means required value is at last column.

Don, please correct me if my assumption was wrong.

Hope, it mat useful to you.

grep -vw "21" input_file > output_file

Please post two records which contains 21 and 542178, then I can provide you the sed command.