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Works brilliantly!!! Thank you ahamed!

I made one slight adjustment so as to retain the unique id along with the core string:
awk 'NR==FNR{split($2,c,",");split($3,b,",");a[$1]=c[2]" "b[1];...

Worked BRILLIANTLY!!! Thank you ahamed!

Hello all, this might be better suited for a bioinformatics forum, but I thought I'd try my luck here as well.

I have several tabular text files of DNA sequence reads that appear as such:
...