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The system load is far too high compared to the user load.

You should investigate what processes and what system calls are consuming that much kernel time.

Start with runningprstat -mZ -n 30 -c...

None of your disks seems to be all that busy - the service times are all really good. The vmstat output doesn't look exceptional.

Yet the Sybase DB processes are pegging their CPUs.

Looks like...

If they're looking at end-user performance issues I'd have the Sybase DBA's check the databases as well. Make sure that they don't need some tuning.

Forget "top". That's inaccurate enough on a Solaris box with just a few CPUs.

What's "prstat -a" and "vmstat 2 20" show when the machine is slow?

How about "iostat -sndxz 2 20"?

FWIW, there...

The runq-sz isn't that high, given the number of cores (40).

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