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Any attempt from your side?

---------- Post updated at 17:20 ---------- Previous update was at 17:19 ----------

Howsoever, tryawk '{for (i=4; i<=NF; i++) $i*=$3}1' file
rs1000012 AK8 2 0.1 0.1...

awk -f fadista.awk myInputFile
OR
for the 9-th column
awk -v c=9 -f fadista.awk myInputFile

function genrand(n)
{
return (int(n*rand())+1);
}

BEGIN {
if (!c) c=2;
srand()
}
{...

try:
awk '
NR==FNR {a[$1" "$2]=$1" "$2" "$3;}
{if (!ff[FILENAME]) {f[fc++]=FILENAME;ff[FILENAME]=FILENAME}}
{b[$1" "$2]=$1" "$2;c[$1" "$2" "FILENAME]=$NF;}
END {
for (i=0; i<fc; i++) for (j...