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try this


awk -F, '{for(i=4;i<=NF;i++){s+=$i}{$(NF+1)=s;s=0}}1' OFS="," file

awk -F, '{for(i=4;i<=NF;i++){s+=$i}{$(NF+1)=s}}1' OFS="," file

or:
awk -F, 'BEGIN{OFS=","}{for(i=4;i<=NF;i++)s+=$i;print $0,s}' infile > another_file