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Some ways:
VAR1="000004785"
echo "$VAR2" | sed "s/\([^0-9]*\)[0-9]*\(.*\)/\1$VAR1\2/"

or:
VAR1="000004785"
echo "$VAR2" | sed "s/\(......\).........\(.*\)/\1$VAR1\2/"

One more (minor variation of Franklin52's second option):
sed "s/\(.\{6\}\).\{9\}/\1$VAR1/"

Regards,
Alister

bash 4
# VAR1=000004785
# VAR2="ACCTRL000005022RRWDKKEEDKDD...."
# VAR2=${VAR2:0:6}${VAR1}${VAR2:15}
# echo $VAR2
ACCTRL000004785RRWDKKEEDKDD....