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There are many many ways you could to this. With grep, for instace:grep -v '^.........................T' inputfile(there should be 25 ".")

With awk, I'd:awk 'substr($0, 26, 1) != "T"' inputfileI...

That change doesnt look like its at position 11. It looks like position 5.

I couldnt resist a sed solution for that

sh-2.05b$ echo "456781 ~Y~12345" | sed -e 's#\(.\{5\}\)\(.*\)#\1~\2#g'...