When attempting to connect iPhone or iPod touch, you may see one or more of the following error messages: iTunes could not connect to this iPhone because an unknown error occurred (0xE8000065) iTunes could not connect to this iPhone because an unknown error occurred (0xE800000a) iTunes could not connect to this iPhone because an unknown error occurred (0xE800006b) iTunes could not connect to this iPhone because an unknown error occurred (0xE8000001) Alternatively, the error may be the same as above but end with a different number. The following steps may resolve the issue.
More from Apple OS X Support ...