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Here is one way:
sed '/152.15.x.y/d;/152.9.x.y/d;/152.19.x.y/d;/44.33.x.y/d' /etc/hosts

Once you know the sed command works as expected, you can use the -i option to replace the file you just edited.

Also, Shell_Life's example makes one big mistake: using unescaped periods (.) to...