COPASI is a software application for modeling and simulation of biochemical networks. The software package has a GUI that lets users define biochemical network models by entering chemical reactions and kinetic equations. A powerful simulation engine can then perform simulations of the dynamics of the networks and carry out many different computational analyses. COPASI can simulate dynamics using either an ODE approach or a stochastic chemical kinetics approach (Gillespie-type algorithms). License: Free for non-commercial use Changes:
Compartment volumes can now be determined by ODEs or initial assignments. Initial assignments are now allowed. There are new optimization methods: Truncated Newton and Praxis. There is a new tool that checks rate laws for possible problems. Import and export of SBML files has been improved. The mass conservation analysis task is now available on the command line version. There is a new command line option to only validate the input files. There are many bugfixes.

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