ClonalFrame(1) General Commands Manual ClonalFrame(1)
NAME
ClonalFrame - inference of bacterial microevolution using multilocus sequence data
SYNOPSIS
ClonalFrame [OPTIONS] inputfile outputfile
DESCRIPTION
ClonalFrame identifies the clonal relationships between the members of a sample, while also estimating the chromosomal position of homolo-
gous recombination events that have disrupted the clonal inheritance.
Options:
-x NUM Sets the number of iterations after burn-in (default is 50000)
-y NUM Sets the number of burn-in iterations (default is 50000)
-z NUM Sets the number of iterations between samples (default is 100)
-e NUM Sets the number of branch-swapping moves per iterations (default is so that half of the time is spent branch-swapping)
-m NUM Sets the initial value of theta to NUM (default is Watterson estimate)
-d NUM Sets the initial value of delta to NUM (default is 0.001)
-n NUM Sets the initial value of nu to NUM (default is 0.01)
-r NUM Sets the initial value of R to NUM (default is initial theta/10)
-M Do update the value of theta
-D Do not update the value of delta
-N Do not update the value of nu
-R Do not update the value of R
-T Do not update the topology
-A Do not update the ages of the nodes
-G Remove all gaps
-H Remove all gaps at non-polymorphic positions
-t NUM Indicate which initial tree to use: 0 for a null tree, 1 for a uniformly chosen coalescent tree and 2 for UPGMA tree (default)
-w FILE
Use Newick file for initial tree
-a NUM Sets the first parameter of the beta prior distribution of nu
-b NUM Sets the second parameter of the beta prior distribution of nu
-U Use uniform priors for rho, theta and delta
-B Run in BURST mode
-C Run in UPGMA mode with a site-by-site bootstrap procedure
-c Run in UPGMA mode with a fragment-by-fragment bootstrap procedure
-S NUM Sets the seed for the random number generator to NUM
-E NUM Sets the rate of exponential growth (default is 0)
-I Ignores first block in the alignment
-L Clean-up the alignment before running ClonalFrame
-l Minimum distance between two reference sites (default is 50)
-v Verbose mode
AUTHOR
ClonalFrame was written by Xavier Didelot.
This manual page was written by Andreas Tille <tille@debian.org>, for the Debian project (but may be used by others).
February 2011 1.2 ClonalFrame(1)