@Scrutinizer
A very nice solution. I did use nearly one hour to study this simple work to find out how it works. I do admire how you guys manage to find this clever simple solution to the problems.

I just like to explain how this script work, so I have written it some more readable.

Code:

awk -F' *,' '		#1	
p!=$1{			#2
	if(p) print s;	#3
	s=$3 OFS $1;	#4
	p=$1}		#5
{s=s OFS $2} 		#6
END {print s}' \	#7
OFS='\t' file		#8

#1 Setting the Field separator to one or more spaced followed by a comma ' *,'

Run on line one 22057485 ,219 ,1050
$1=22057485 $2=219 $3=1050
#2 test if p is different form $1, and it is since p=0 (no data)
#3 test if p contains data, no, p is blank, do not print.
#4 set s=$3 OFS $1 s="1050 22057485"
#5 p=$1=22057485
#6 s=s OFS $2 s="1050 22057485 219"
Run on line two 22057485 ,223 ,1050
$1=22057485 $2=223 $3=1050
#2 test if p is different form $1, and it equal p=22057485 $1=22057485
Jump to #6
#6 s=s OFS $2 s="1050 22057485 219 223"
Run on line three 21897425 ,278 ,1050
$1=21897425 $2=278 $3=1050
#2 test if p is different form $1, and it is since p=22057485 $1=21897425
#3 test if p contains data, yes print s 1050 22057485 219 223
#4 set s=$3 OFS $1 s="1050 21897425"
#5 p=$1=21897425
#6 s=s OFS $2 s="1050 21897425 278"
Run on line four
.
.
.
#7 END Last job, print the last line print s
#8 setts the Output Field Separator to tab OFS='\t'