You could look at rsync+ssh, and give ssh the "blowfish" encryption option as it is supposed to be faster than the default.
Like so:
Code:
rsync -avz --ignore-existing -e 'ssh -oConnectTimeout=10 -c blowfish -ax' source-file destserver:/dest/path
Advantage of rsync is that it can resume a broken transfer.
You could also try regular scp with:
[ -C is for compression ]
You could also try piping the large file through tar+gzip as described here:
here and
here
If you can download using HTTP,
aget is another option.
All this may not make much of an impact if your file cannot be compressed, or if your network is too slow.